Pharmaceutical Development Services
Detailed investigations
When a client approaches us, we start by discussing possible analytical strategies and developing a customised research package.
It is impossible to list every type of question we get asked during development, scale-up and manufacturing but here is an at-a-glance view of the types of issues we work to resolve:
Pharmaceutical
- API batch-to-batch processing variability
- Unwanted drug cohesion / aggregation / agglomeration
- Drug instability
- Problems with flow / compaction and granulation
- Formulation out of specification root cause analysis
- Formulation instability
- Advanced imaging to optimise formulation process
- Changes on scale-up
- Supplier changes
- Assessment of optimum processing properties
- Surface chemical optimisation
- Controlled release coating failures
Biopharmaceutical
- Optimisation of lyophilised and polymeric based products
- Solid state analysis for optimisation of colloidal, nanoparticulate and microparticulate products
- Chemical mapping and imaging to study content uniformity
- Aggregation studies
- Formulated product–tertiary and solid state structural determination
- Surface analysis and optimisation of delivery systems
- Ligand-receptor binding studies